A wavefront-based constraint for potential surface solutions in inverse electrocardiography

Inverse electrocardiography in recent years has generally been approached using one of two quite distinct source models, either a potential-based approach or an activation-based approach. Each approach has advantages and disadvantages relative to the other, which are inherited by all specific methods based on a given approach. Recently our group has been working to develop models which can bridge between these two approaches, hoping to capture some of the most important advantages of both. In this work we present one such effort, which we term wavefront-based potential reconstruction (WBPR). It is a modification of standard regularization methods for potential-based inverse electrocardiography, into which we incorporate a constraint based on a wavefront-like approximation to the potential-based solution. Initial results indicate significant improvement with respect to localization and characterization of the wavefront in simulations using both epicardially and supra-ventricularly paced heartbeats