Realization assessment of stabilizer with presonication on size-distribution of itraconazole nanoparticulate in wet-nanomilling

The paper investigates fabrication of itraconazole nanoparticulate in wet-nanomilling by appropriate alteration of the suspension properties and the milling parameters. By wet-nanomilling, stable nano-scale particulate can be prepared which have better physical properties. In this study, effects of adding stabilizer on nanoparticulate size and polydispersity index were performed during production of itraconazole nanoparticulate. In addition, the effect of pre-sonication followed by wet grinding was assessed on the particulate size of itraconazole in dispersion containing stabilizer. The size of drug particulate was reduced to less than 200 nm with a polydispersity index (PDI) below 1.0 thus influencing the milling process under these conditions.