Applying DNA computing to diagnose-and-interfere hepatic fibrosis

In the last few years, advances in molecular computing have been developed fast enough to offer several paradigms of diagnosis and therapeutic applications. Herein we describe how molecular computing can be applied to detect activated hepatic stellate cells (HSC) -which are well known as the main responsible of hepatic fibrogenesis- and, as a response to positive diagnosis, express a gene (PPAR_γ1) which have been proved to reverse the myofibroblast-like phenotype of the HSC in vivo. We also propose a transport method to deliver the DNA computer into the HSC; namely, vitamin A-coupled liposomes.