Neural circuitry mediating locomotion in C. elegans : molecular correlates of inhibitory motor neurons

In the nematode Caenorhabditis elegans, sinusoidal locomotion is mediated through six motor neurons: DA, VA, DB, and VB are excitatory; DD and VD are inhibitory motor neurons. The author has previously identified all antitubulin McAb (2-28-33) that brightly stains DD and VD motor neurons and seven other neurons in C. elegans. Mutations in 14 genes that affect the axonal growth and guidance of DD and VD axonal processes have been identified. The staining pattern of 2-28-33 matches the pattern of anti-GABA antibodies staining in C. elegans, suggesting a correlation between molecular markets and the neurons forming a functionally related network