Determining the absorption coefficient of hemoglobin derivatives with integrated optic waveguide sensor

Author

Kang, Shin-Won ; Sasaki, Keisuke ; Minamitani, Haruyuki

Author_Institution

Dept..of Biomed. Eng., Keio Univ., Yokohama, Japan

Volume

1

fYear

1992

fDate

Oct. 29 1992-Nov. 1 1992

Firstpage

171

Lastpage

172

Abstract

A simple method of determining the absorption coefficient of absorbing aqueous biochemicals is proposed as an application of the complex propagation constant of guided wave in a thin-film optical waveguide. It was designed to consecutively change the interaction length between the evanescent field and the sample, and evaluated by prism couplers. The response linearly depends on the interaction length and the total hemoglobin concentration(THb ) of hemoglobin derivatives. The determined absorption coefficients fairly well coincide with the values obtained by the conventional transmission measurement.

Keywords

absorption coefficients; biochemistry; biosensors; chemical sensors; molecular biophysics; optical couplers; optical planar waveguides; optical prisms; optical sensors; proteins; absorbing aqueous biochemicals; absorption coefficient; evanescent field; hemoglobin concentration; hemoglobin derivatives; integrated optic waveguide sensor; prism couplers; thin-film optical waveguide; transmission measurement; Chemical lasers; Laser modes; Optical coupling; Optical sensors; Optical variables control; Optical waveguides; Sputtering;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1992 14th Annual International Conference of the IEEE

Conference_Location

Paris

Print_ISBN

0-7803-0785-2

Electronic_ISBN

0-7803-0816-6

Type

conf

DOI

10.1109/IEMBS.1992.5760911

Filename

5760911