Explore the domain features of co-regulation proteins, co-interaction proteins and co-regulation & Co-interaction proteins

The interaction between proteins is one of the most important features of protein functions. Behind protein-protein interactions there are relationship among protein domains physically to perform the necessary functions. Accordingly, we focus on our research on the domain features of co-regulation proteins sets, co-interaction proteins sets and co-regulation & co-regulation proteins sets. We applied aggregation factors to evaluate the domain features about above three protein sets. By random experiment, we approved that the aggregation factors were significant (p<;0.01) in these three protein sets. That is to say, the same domains present more frequency in them than in other protein subsets. Furthermore, our results also showed that the same domains present more frequency in co-regulation & co-interaction subsets than in co-regulation subsets, which indicated that co-regulation protein sets & co-interaction protein sets are more likely protein sets which have the same domains.