Infrared photon discrimination of lung cancer cells

Author

Giakos, G.E. ; Shrestha, S. ; Petermann, J. ; Narayan, E. ; Marotta, S. ; Despande, A. ; Syms, J. ; Farrahi, T. ; Blinzler, A. ; Picard, R.H. ; Inbody, W. ; Dao, Phan D. ; Crabtree, P.N. ; McNicholl, Patrick J. ; Zhang, L. ; Zhou, A. ; Zervakis, M. ; Koun

Author_Institution

Dept. of Electr. & Comput. Eng., Univ. of Akron, Akron, OH, USA

fYear

2012

fDate

16-17 July 2012

Firstpage

637

Lastpage

642

Abstract

The objective of this study is to explore the polarimetric phenomenology of near infrared light interaction with healthy and lung cancer monolayer cells by using efficient polarimetric transmission detection techniques. Preliminary results indicate that enhanced discrimination between normal and different types of lung cancer cell stages can be achieved based on their transmitted intensities and depolarization properties of the cells. Specifically, the sizes of the nuclei of the cancer cells and the nucleus-to-cytoplasmic ratios appear to have potential impact on the detected polarimetric signatures leading to enhanced discrimination of lung cancer cells.

Keywords

bio-optics; cancer; cellular biophysics; light transmission; lung; patient diagnosis; polarimetry; cell depolarization property; cell transmitted intensity; healthy lung monolayer cells; infrared photon based discrimination; lung cancer cell discrimination; lung cancer monolayer cells; near infrared light interaction; nucleus-cytoplasmic ratio; polarimetric phenomenology; polarimetric transmission detection techniques; Cancer; Generators; Geometry; Heating; Laser modes; Lead; Measurement by laser beam; Adenocarcinoma; Efficient discrimination; Lung squamous carcinoma; Mixture of cancer cells; Near infrared light; Polarimetric phenomenology; Polarization signatures; nuclei size; nucleus-to-cytoplasmatic ratio;

fLanguage

English

Publisher

ieee

Conference_Titel

Imaging Systems and Techniques (IST), 2012 IEEE International Conference on

Conference_Location

Manchester

Print_ISBN

978-1-4577-1776-5

Type

conf

DOI

10.1109/IST.2012.6295599

Filename

6295599