Effects of reverberations and clutter filtering in pulsed Doppler using sparse sequences

Duplex ultrasound is a modality in which an ultrasound system is used for simultaneous acquisition of both B-mode images and velocity (Doppler) data. Conventional duplex sequences interleave packets of B-mode and Doppler transmissions, producing undesirable gaps during B-mode interruptions. In recent years, several techniques have been proposed for avoiding such gaps by using sparse sequences, in which velocity spectra are generated from nonuniformly sampled Doppler data containing frequent B-mode interruptions. In this work, two negative effects are discussed that may influence velocity estimation when using nonuniformly sampled sequences. First, it is shown that long reverberation times lead to discontinuities in the signal from stationary clutter after each B-mode interruption. Second, using frequency analysis, it is shown that clutter filtering of nonuniformly sampled data may introduce artifacts in the velocity spectrum, and also lead to significant bias in mean velocity estimates. Methods are presented for quantification of these effects, and utilized to analyze three types of sparse duplex sequences for blood velocity estimation. In particular, it is argued that the use of such sequences in cardiac applications is not recommended because of long reverberation time. Additionally, it is found that the use of regression filters to filter nonuniformly sampled data may produce significant artifacts in pulsed wave Doppler spectra, but is less significant for color Doppler imaging applications. In vitro and in vivo examples are included showing the presence and magnitude of these problems in clinically relevant applications.