Modified inverse solution to one dipole for location of lesions with changed repolarization

The aim of the simulation study was to modify the method for localization of one lesion with changed repolarization by inverse solution to one dipole to improve the localization error especially in the cases of large and transmural lesions. The effect of one lesion was suggested to be represented by group of neighboring dipoles with the mean adjacent distance of 1 cm. The influence of number of dipoles in the group on the localization error was studied on simulated ECG data using analytically defined model of heart placed in inhomogeneous torso model. For comparison, analogical study was performed on ECG data simulated by the ECGSIM software. The mean localization error for large/transmural lesions improved significantly from 2.3 cm to 1.0 cm or 1.3 cm for analytical or ECGSIM heart model when the group of five neighboring dipoles was used in the inverse solution instead of one dipole. The suggested method makes it possible to obtain comparable accuracy of the inverse solution regardless of the size of modeled lesion.