A neurochemical pattern generator SoC with switched-electrode management for single-chip electrical stimulation and 9.3µW, 78pArms, 400V/s FSCV sensing

This paper describes a system-on-chip (SoC) fabricated in 0.35μm 2P/4M CMOS for high-fidelity neurochemical pattern generation in vivo. The SoC uniquely integrates electrical stimulation with embedded timing management and 400V/s fast-scan cyclic voltammetry (FSCV) sensing, and manages a novel switched-electrode scheme that eliminates the possibility of large stimulus artifacts adversely affecting electrochemistry. The SoC also leverages the discontinuous sampling inherent in FSCV to reduce the power consumption per sensing channel by ~88% vs. state-of-the-art. The correlation coefficient between the predicted and measured temporal profiles of electrically evoked dopamine in the brain of an anesthetized rat is 0.95.