Changes in the behavior of magnetic iron oxide nanoparticles during cellular uptake detected by magnetic particle spectroscopy

Author

Wiekhorst, F. ; Lowa, N. ; Poller, W. ; Metzkow, S. ; Ludwig, A. ; Trahms, L.

Author_Institution

Phys.-Tech. Bundesanstalt, Charite - Universitatsmed. Berlin, Berlin, Germany

fYear

2015

fDate

26-28 March 2015

Firstpage

1

Lastpage

1

Abstract

Cell-labeling with very small superparamagnetic iron oxide nanoparticles (VSOP) for MRI cell tracking requires methods for reliably assessment of labeling efficacy prior to the in-vivo application. Magnetic particle spectroscopy (MPS) enables sensitive and specific detection of nanoparticles in biological systems. Here, it has been used to quantify the cellular uptake of iron oxide nanoparticles. Furthermore, magnetic changes in the MPS spectra during cellular uptake were correlated with cellular nanoparticle processing.

Keywords

biomagnetism; biomedical MRI; cellular biophysics; iron compounds; magnetic particles; nanomedicine; nanoparticles; superparamagnetism; MPS spectra; MRI cell tracking; biological systems; cellular nanoparticle processing; cellular uptake; in-vivo application; labeling efficacy; magnetic iron oxide nanoparticles; magnetic particle spectroscopy; Harmonic analysis; Iron; Labeling; Magnetic particles; Magnetic resonance imaging; Nanoparticles; Spectroscopy;

fLanguage

English

Publisher

ieee

Conference_Titel

Magnetic Particle Imaging (IWMPI), 2015 5th International Workshop on

Conference_Location

Istanbul

Print_ISBN

978-1-4799-7269-2

Type

conf

DOI

10.1109/IWMPI.2015.7107009

Filename

7107009