Optimizing nanoparticle selection and drive field properties for simultaneous MPI and hyperthermia

Author

Thangavel, Kalaivani ; Utkur, Mustafa ; Saritas, Emine Ulku

Author_Institution

Nat. Magn. Resonance Res. Center (UMRAM), Bilkent Univ., Ankara, Turkey

fYear

2015

fDate

26-28 March 2015

Firstpage

1

Lastpage

1

Abstract

This paper investigates the properties of superparamagnetic iron oxide (SPIO) nanoparticles for simultaneous MPI imaging and hyperthermia therapy. For that purpose, FeraSpin SPIO nanoparticles of varying sizes (FeraSpin XS to FeraSpin XL, with hydrodynamic diameters ranging between 10 nm to 70 nm) with different concentrations (~ μM to mM) are utilized to investigate their MPI and heating efficiencies (i.e., specific absorption rate - SAR) as a function of applied magnetic field. Once the setup is fully functional, our results will provide a proof-of-concept for a potential application of MPI: simultaneous hyperthermia and imaging.

Keywords

biomedical MRI; hyperthermia; iron compounds; magnetic particles; nanomedicine; nanoparticles; radiation therapy; superparamagnetism; Fe₂O₃; FeraSpin SPIO nanoparticles; MPI; SAR; drive field properties; heating efficiencies; hyperthermia therapy; magnetic particle imaging; nanoparticle selection; specific absorption rate; superparamagnetic iron oxide nanoparticles; Heating; Hyperthermia; Imaging; Magnetic fields; Magnetic liquids; Magnetic particles; Nanoparticles;

fLanguage

English

Publisher

ieee

Conference_Titel

Magnetic Particle Imaging (IWMPI), 2015 5th International Workshop on

Conference_Location

Istanbul

Print_ISBN

978-1-4799-7269-2

Type

conf

DOI

10.1109/IWMPI.2015.7107038

Filename

7107038