Individualized T1DM simulator for verification of adaptive controller

Author

Ottinger, Ivan ; Ludwig, Tomas ; Miklovicova, Eva ; Batora, Vladimir ; Murgas, Jan ; Tarnik, Marian

Author_Institution

Inst. of Robot. & Cybern., Slovak Univ. of Technol. in Bratislava, Bratislava, Slovakia

fYear

2015

fDate

9-12 June 2015

Firstpage

338

Lastpage

343

Abstract

Individualized type 1 diabetes mellitus (T1DM) subject model is presented in this paper. Insulin-glucose subsystem based on Bergman´s minimal model is coupled with subcutaneous insulin absorption and absorption of digested carbohydrates. Identification of model parameters was performed on pharmacokinetics and pharmacodynamics characteristics of administered insulin and data collected from continuous glucose monitoring (CGM) system. The identified model served as a basis for designing a model reference adaptive controller.

Keywords

control system synthesis; diseases; medical control systems; model reference adaptive control systems; Bergman minimal model; CGM system; adaptive controller verification; continuous glucose monitoring; digested carbohydrates absorption; individualized T1DM simulator; individualized type 1 diabetes mellitus; insulin-glucose subsystem; model parameters identification; model reference adaptive controller design; pharmacodynamics characteristics; pharmacokinetics characteristics; subcutaneous insulin absorption; Absorption; Adaptation models; Data models; Diabetes; Insulin; Mathematical model; Sugar;

fLanguage

English

Publisher

ieee

Conference_Titel

Process Control (PC), 2015 20th International Conference on

Conference_Location

Strbske Pleso

Type

conf

DOI

10.1109/PC.2015.7169986

Filename

7169986