Factors influencing the biocompatibility of insertable silicon microshafts in cerebral cortex

Author

Edel, David J. ; Toi, V.V. ; McNeil, Vincent M. ; Clark, Lloyd D.

Author_Institution

Harvard-MIT Div. of Health Sci. & Technol., Cambridge, MA, USA

Volume

39

Issue

6

fYear

1992

fDate

6/1/1992 12:00:00 AM

Firstpage

635

Lastpage

643

Abstract

Issues that determine the biocompatibility of insertable microelectrode arrays were investigated. Results from a limited number of tests indicated that there was minimal tissue response along the sides of the shafts when shafts were well sharpened, had sufficiently small tip angles, and were clean. Tissue was usually more reactive at the tips of the shafts. It was concluded that silicon microshafts of appropriate shaft and tip design were biocompatible along the sides of the shaft, but that relatively severe reactions could be anticipated at the tips.

Keywords

brain; microelectrodes; Si microshafts; biocompatibility; cerebral cortex; insertable microelectrode arrays; tip angle; tissue response; Cerebral cortex; Density measurement; Electrodes; Insulation; Microelectrodes; Neural prosthesis; Neurons; Rabbits; Shafts; Silicon; Animals; Biocompatible Materials; Cerebral Cortex; Electrodes, Implanted; Equipment Design; Gliosis; Microelectrodes; Rabbits; Silicon;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/10.141202

Filename

141202