Magnetic Resonance and Light Microscopy Investigation of Raw Cells Treated With Dextran-Based Magnetic Fluid

Author

Lacava, Zulmira G M ; Lacava, Leandro M. ; Fonseca, Marcio J P ; Souza, Thiago M M ; Pereira, Luciana O. ; Silva, Osni ; Pelegrini, Fernando ; Sabolovic, Domagoj ; Sestier, Claude ; Azevedo, Ricardo ; Buske, Norbert ; Morais, Paulo C.

Author_Institution

Inst. de Biologia, Univ. de Brasilia

Volume

42

Issue

10

fYear

2006

Firstpage

3599

Lastpage

3601

Abstract

In the present study, magnetic resonance (MR) and light microscopy (LM) were used to investigate in vitro effects of dextran-coated magnetic nanoparticles (MNPs) on mouse Raw cells. LM showed the increasing internalization and metabolization of MNPs. MR allowed determination of fundamental parameters, such as the MNP internalization half-life (t_1/2). The data evidenced that MR can be used as a key spectroscopic technique to investigate MNP internalization and cell/tissue interaction processes in biological systems

Keywords

cellular biophysics; magnetic fluids; magnetic particles; magnetic resonance spectroscopy; nanoparticles; optical microscopy; cell-particle interaction; dextran; light microscopy; magnetic fluids; magnetic resonance; magnetite nanoparticle; raw cells; Biological systems; Biological tissues; Cells (biology); In vitro; Magnetic force microscopy; Magnetic liquids; Magnetic resonance; Mice; Nanoparticles; Spectroscopy; Cell-particle interaction; Raw cells; magnetic fluid; magnetic resonance; magnetite nanoparticle;

fLanguage

English

Journal_Title

Magnetics, IEEE Transactions on

Publisher

ieee

ISSN

0018-9464

Type

jour

DOI

10.1109/TMAG.2006.879448

Filename

1704705