A model of the pacemaking neuron of the respiratory central pattern generator

Author

Amini, Behrang ; Bidani, Akhil ; Zwischenberger, Joseph B. ; Clark, John W., Jr.

Author_Institution

Dept. of Neurobiol. & Anatomy, Univ. of Texas Health Sci. Center, Houston, TX, USA

Volume

13

Issue

2

fYear

2005

fDate

6/1/2005 12:00:00 AM

Firstpage

120

Lastpage

124

Abstract

We have developed a model of the mammalian respiratory central pattern generator (rCPG) to mimic the salient characteristics of its constituent medullary neurons. This model is designed as a network of Hodgkin-Huxley-type medullary neurons driven by a pacemaking neuron from the pre-Bötzinger complex. Here, we present the results of our model of this pacemaking neuron, based on available voltage clamp data. Implications for the behavior of the rCPG are discussed.

Keywords

neurophysiology; physiological models; pneumodynamics; Hodgkin-Huxley-type medullary neurons; mammalian respiratory central pattern generator; pacemaking neuron model; preBotzinger complex; Biological neural networks; Character generation; Circuits; Clamps; Modeling; Neurons; Neuroscience; Respiratory system; Temperature; Voltage; Biological system modeling; Hodgkin–Huxley models; neural networks; respiratory system; Action Potentials; Animals; Biological Clocks; Computer Simulation; Feedback; Humans; Lung; Medulla Oblongata; Models, Neurological; Nerve Net; Respiratory Mechanics; Synaptic Transmission;

fLanguage

English

Journal_Title

Neural Systems and Rehabilitation Engineering, IEEE Transactions on

Publisher

ieee

ISSN

1534-4320

Type

jour

DOI

10.1109/TNSRE.2005.847379

Filename

1439534