A bidomain model of epiretinal stimulation

Author

Dokos, Socrates ; Suaning, Gregg J. ; Lovell, Nigel H.

Author_Institution

Graduate Sch. of Biomed. Eng., Univ. of New South Wales, Sydney, NSW, Australia

Volume

13

Issue

2

fYear

2005

fDate

6/1/2005 12:00:00 AM

Firstpage

137

Lastpage

146

Abstract

A computational bidomain model of epiretinal stimulation is presented, consisting of a continuum description of active retinal tissue in contact with bulk vitreous fluid. Results from two-electrode and four-electrode bipolar stimulation suggest that a biphasic cathodic-anodic stimulus sequence is effective in providing targeted focal activation of retinal tissue. Undesired secondary activations beneath each electrode return may be eliminated by using multiple returns for each stimulus electrode.

Keywords

bioelectric potentials; biological tissues; biomedical electrodes; eye; neurophysiology; physiological models; prosthetics; active retinal tissue; bioelectric potentials; biphasic cathodic-anodic stimulus sequence; bipolar stimulation; bulk vitreous fluid; computational bidomain model; epiretinal stimulation; neuroprosthesis; Anisotropic magnetoresistance; Australia; Biomedical engineering; Computational modeling; Conductivity; Electrodes; Extracellular; Neurons; Retina; Voltage; Bioelectric potentials; charge injection; electrodes; modeling; neuroprosthesis; visual system; Action Potentials; Animals; Computer Simulation; Electric Stimulation; Electrodes, Implanted; Humans; Microelectrodes; Models, Neurological; Nerve Net; Retinal Ganglion Cells; Visual Fields; Visual Perception;

fLanguage

English

Journal_Title

Neural Systems and Rehabilitation Engineering, IEEE Transactions on

Publisher

ieee

ISSN

1534-4320

Type

jour

DOI

10.1109/TNSRE.2005.847390

Filename

1439537