Light microscopy and magnetic resonance characterization of a DMSA-coated magnetic fluid in mice

Author

Chaves, S.B. ; Lacava, L.M. ; Lacava, Z.G.M. ; Silva, O. ; Pelegrini, F. ; Buske, N. ; Gansau, C. ; Morais, P.C. ; Azevedo, R.B.

Author_Institution

Inst. de Ciencias Biologicas, Brasilia Univ., Brazil

Volume

38

Issue

5

fYear

2002

fDate

9/1/2002 12:00:00 AM

Firstpage

3231

Lastpage

3233

Abstract

Light microscopy and magnetic resonance were used to investigate the biodistribution of magnetite nanoparticles coated with dimercaptosuccinic acid, after intravenous injection of a single dose in mice. Morphological analysis showed a huge amount of magnetic nanoparticles (MNPs) in the lung 30 min after injection. In contrast to the lung, morphological analysis revealed lower concentration of MNPs in the liver. A progressive decrease of MNPs in both lung and liver was observed from 30 min to 4 hours after intravenous injection. MNPs were not observed in any other organs using morphological analysis. In support of the LM observations MR signals were detected in both lung and liver as early as 5 min after injection. In addition, no MR signal was observed in the blood stream as early as 5 min after injection of the single dose.

Keywords

biological techniques; biomagnetism; ferrites; liver; lung; magnetic fluids; magnetic particles; magnetic resonance; optical microscopy; organic compounds; 30 min to 4 hour; 5 min; DMSA-coated magnetic fluid; Fe₃O₄; anticancer drug-carrier precursor; biocompatibility; blood stream; brain; dimercaptosuccinic acid; heart; kidney; light microscopy; liver; lung; magnetic resonance characterization; magnetite nanoparticle biodistribution; mice; morphological analysis; organs; pancreas; single intravenous injection dose; spleen; Blood; Liver; Lungs; Magnetic analysis; Magnetic force microscopy; Magnetic liquids; Magnetic resonance; Mice; Nanoparticles; Signal detection;

fLanguage

English

Journal_Title

Magnetics, IEEE Transactions on

Publisher

ieee

ISSN

0018-9464

Type

jour

DOI

10.1109/TMAG.2002.802495

Filename

1042507