مقايسه سطح IL-23 در مايع شيار لثه اي بيماران مبتلا به التهاب اطراف ايمپلنت با افراد داراي بافت پري ايمپلنت سالم

Comparison of of Interleukin 23 Level in Gingival Crevicular Fluid between Peri-implantitis and Healthy Patients

Introduction: Peri-implantitis is characterized by irreversible lesions that are caused by microbial plaque, involving not only the soft tissue around the implant, but also the implant-supporting bone. In the peri-implant diseases, some cytokines are increased, and inflammatory mediators, which are observed in peri-implantitis, induce the activation of osteoclasts and bone resorption. The aim of this study was to compare the level of interleukin 23 (IL-23) in patients with peri-implantitis and those with healthy peri-implant tissue. Materials & methods: This clinical trial was conducted on 19 patients with peri-implantitis and 19 patients with healthy peri-implant tissue. The samples were collected from sulcular fluid/gingival pocket fluid by paper cone and placed in vials. The level of IL-23 was determined using ELISA reader. Furthermore, the relationship of IL-23 levels with bleeding, probing depth, and pus formation was analyzed. Data analysis was performed using independent t-test, Pearson correlation coefficient, and Spearman test. Results: According to the results, the level of IL-23 in the patients with peri-implantitis was significantly higher than that in the group with healthy peri-implant tissue (P<0.001). Furthermore, the level of IL-23 showed a direct relationship with probing depth (P=0.008), bleeding on probing (P=0.01), and pus formation (P<0.001) in the patient group. Conclusion: As the findings indicated, the amount of IL-23 in the gingival fluid of the patients with peri-impinitis was higher than that of the healthy subjects. Probing depth, bleeding, and pus formation are directly associated with IL-23. Therefore, the evaluation of IL-23 level can be used in the diagnosis of peri-implantitis