مقايسه قواعد ساخت داروهاي تركيبي در داروسازي سنتي ايراني و چيني

Comparison of Drug Combination Rules in Traditional Iranian and Chinese Medicine

ﺳﺎﺑﻘﻪ ﻭ ﻫﺪﻑ: ﺍﺯ ﺁﻧﺠﺎ ﻛﻪ ﺍﺳﺘﺮﺍﺗﮋﻱ ﻃﺐ ﺳﻨﺘﻲ ﺗﻌﺮﻳﻒ ﺷﺪﻩ ﻱ ﺳﺎﺯﻣﺎﻥ ﺑﻬﺪﺍﺷﺖ ﺟﻬﺎﻧﻲ ﺩﺭ ﺳﺎﻟﻬﺎﻱ 2014-2023 ﺑﺮ ﺗﺤﻘﻴﻘﺎﺕ ﮔﺴـﺘﺮﺩﻩ ﺗﺄﻛ ﻴـﺪ ﺩﺍﺭﺩ، ﻳـﻚ ﺣﻴﻄـﻪ ﻱ ﺍﺳﺎﺳﻲ ﺑﺤﺚ ﺳﺎﺧﺖ ﺩﺍﺭﻭﻫﺎﻱ ﺗﺮﻛﻴﺒﻲ ﺍﺳﺖ ﻛﻪ ﺩﺭ ﻗﺮﺍﺑﺎﺩﻳﻦ ﻛﺒﻴﺮ ﻧﻴﺰ ﺑﻌﻨﻮﺍﻥ ﺑﻬﺘﺮﻳﻦ ﻋﻠﻮﻡ ﺑﻴﺎﻥ ﺷﺪﻩ ﺍﺳﺖ. ﺑﻪ ﻛﻤﻚ ﺷﻨﺎﺧﺖ ﻗﻮﺍﻋﺪ ﺳﻨﺘﻲ ﺗﺮﻛﻴﺐ ﺩﺍﺭﻭﻫﺎ، ﻣﻲ ﺗﻮﺍﻥ ﺑـﻪ ﺍﺭﺍﻳﻪ ﻱ ﺳﻴﺴﺘﻤﻲ ﻧﻮﻳﻦ ﺩﺭ ﺑﺤﺚ ﺩﺍﺭﻭﻫﺎﻱ ﺗﺮﻛﻴﺒﻲ ﺭﺳﻴﺪ ﻛﻪ ﺩﺭ ﺁﻥ ﻋﻮﺍﺭﺽ ﺟﺎﻧﺒﻲ ﺑﻪ ﺣﺪﺍﻗﻞ ﻣﻤﻜﻦ ﺭﺳﺪ ﻭ ﺍﺛﺮﺑﺨﺸﻲ ﺍﻓﺰﺍﻳﺶ ﻳﺎﺑﺪ. ﻟﺬﺍ ﺍﻳﻦ ﻣﻘﺎﻟﻪ ﺍﺭﺍﺋﻪ ﮔﺮﺩﻳﺪ. ﻣﻮﺍﺩ ﻭ ﺭﻭﺵ ﻫﺎ: ﺍﻳﻦ ﺗﺤﻘﻴﻖ، ﻣﻄﺎﻟﻌﻪ ﺍﻱ ﻣﺮﻭﺭﻱ ﺍﺳﺖ ﻛﻪ ﺩﺭ ﺁﻥ ﺍﺻﻮﻝ ﺗﺮﻛﻴﺐ ﻣﻔﺮﺩﺍﺕ ﺩﺭ ﺳﺎﺧﺖ ﺩﺍﺭﻭﻫﺎﻱ ﺗﺮﻛﻴﺒﻲ ﺳﻨﺘﻲ ﺍﻳﺮﺍﻧﻲ ﻭ ﭼﻴﻨـﻲ ﺑـﻪ ﺻـﻮﺭﺕ ﺟﺪﺍﮔﺎﻧـﻪ، ﺑﻴـﺎﻥ ﺷﺪﻩ ﻭ ﻭﺟﻪ ﺗﺸﺎﺑﻪ ﻳﺎ ﺗﻔﺎﻭﺕ ﺁﻧﻬﺎ ﺗﺤﻠﻴﻞ ﺷﺪﻩ ﺍﺳﺖ. ﺑﺮﺍﻱ ﺑﺨﺶ ﺳﻨﺘﻲ ﺍﻳﺮﺍﻧﻲ ﺍﺯ ﻛﺘﺎﺏ ﻗﺮﺍﺑﺎﺩﻳﻦ ﻛﺒﻴﺮ ﻋﻘﻴﻠﻲ ﻭ ﺑﺨﺶ ﺳﻨﺘﻲ ﭼﻴﻨﻲ، ﺍﺯ ﻛﺘـﺎﺏ (Chinese herbal formulas )treatment principles and composition strategies ﻭ )(Systems biology for herbal medicine ﺍﺳﺘﻔﺎﺩﻩ ﺷﺪ ﻭ ﻣﻘﺎﻻﺕ ﻣـﺮﺗﺒﻂ ﺩﺭ ﭘﺎﻳﮕـﺎﻩ ﻫـﺎﻱ ﺍﻃﻼﻋـﺎﺗﻲ Google Scholar, Sciencedirect, Scopus, Pubmed, nature, embase ﺑـﺎ ﻛﻠﻴـﺪﻭﺍژﻩ ﻫـﺎﻱ complex herbal products in traditional medicine), (combination of herbs, ( composition strategy of herbal formula) ﺩﺭ ﺯﻣﺎﻥ ﺍﺭﺩﻳﺒﻬﺸﺖ ﻣﺎﻩ 94 ﺟﺴﺘﺠﻮ ﺷﺪ. ﻳﺎﻓﺘﻪ ﻫﺎ: ﻃﺐ ﺳﻨﺘﻲ ﺍﻳﺮﺍﻧﻲ ﻭ ﭼﻴﻨﻲ ﺑﺎ ﻭﺟﻮﺩ ﺗﻔﺎﻭﺕ ﻫﺎ ﺩﺭ ﻣﺒﺎﻧﻲ ﭘﺎﻳﻪ ﺍﻱ ﻓﻜﺮﻱ، ﺍﺯ ﻧﻈﺮ ﺍﺻﻮﻝ ﻓﻦ ﺳﺎﺧﺖ ﺩﺍﺭﻭﻫﺎﻱ ﺗﺮﻛﻴﺒﻲ ﻣﺸﺎﺑﻬﺖ ﺯﻳـﺎﺩﻱ ﺩﺍﺭﻧـﺪ ﻭ ﻫـﺮ ﺩﻭ ﺩﺭ ﺑﻴـﺎﻥ ﻋﻠﻞ ﺗﺮﻛﻴﺐ ﺍﺟﺰﺍ ﺑﻪ ﻣﻮﺍﺭﺩ ﻣﺸﺎﺑﻬﻲ ﺍﺷﺎﺭﻩ ﻧﻤﻮﺩﻩ ﺍﻧﺪ ﺍﺯ ﺟﻤﻠﻪ ﺍﺛﺮ ﺗﺄﻛﻴﺪ ﻣﺘﻘﺎﺑﻞ، ﻣﺘﻘﺎﺑﻞ ﺍﻓﺰﺍﻳﻨﺪﻩ، ﻣﺘﻘﺎﺑﻞ ﺧﻨﺜﻲ ﻛﻨﻨﺪﻩ، ﺳـﺮﻛﻮﺏ ﮔـﺮ ، ﺁﻧﺘﺎﮔﻮﻧﻴﺴـﻢ ﻭ ﺍﺛـﺮ ﻧﺎﺳـﺎﺯﮔﺎﺭ . ﻣـﺪﻝ ﺳﺎﺧﺘﺎﺭﻱ ﻓﺮﻣﻮﻝ ﻫﺎﻱ ﺗﺮﻛﻴﺒﻲ ﺩﺭ ﻃﺐ ﺳﻨﺘﻲ ﺍﻳﺮﺍﻧﻲ ﻭ ﭼﻴﻨﻲ ﺍﺯ ﻧﻈﺮ ﺍﺻﻮﻝ ﻣﺸﺎﺑﻬﻨﺪ ﻭ ﺷﺎﻣﻞ ﺍﺟﺰﺍﻱ ﻣﺎﺩﻩ ﻣﺆﺛﺮﻩ، ﻣﻌﻴﻦ، ﺭﺳﺎﻧﻨﺪﻩ ﻭ ﻣﺼﻠﺢ ﻋﻮﺍﺭﺽ ﺟﺎﻧﺒﻲ ﻣﻲ ﺑﺎﺷﻨﺪ. ﻧﺘﻴﺠﻪ ﮔﻴﺮﻱ: ﺩﺍﺭﻭﺩﺭﻣﺎﻧﻲ ﺳﻨﺘﻲ ﻣﻲ ﺗﻮﺍﻧﺪ ﺑﻪ ﺩﺍﺭﻭﺩﺭﻣﺎﻧﻲ ﺭﺍﻳﺞ ﻛﻤﻚ ﻛﻨﺪ. ﺑﺎ ﺷﻨﺎﺧﺖ ﺧﻮﺍﺹ ﺳﻨﺘﻲ ﺍﺟﺰﺍ ﻭ ﺧﺎﺻﻴﺖ ﻛﻠﻲ ﻓﺮﻣﻮﻻﺳﻴﻮﻥ، ﺑﺎ ﺗﺤﻠﻴﻞ ﺟﺎﻳﮕﺎﻩ ﺍﺟﺰﺍﻱ ﻓﺮﻣـﻮﻝ ﺩﺍﺭﻭﻱ ﺗﺮﻛﻴﺒﻲ ﺑﺮ ﺍﺳﺎﺱ ﻣﺪﻝ ﺳﺎﺧﺘﺎﺭﻱ، ﻣﻲ ﺗﻮﺍﻥ ﺩﺍﻣﻨﻪ ﺍﻱ ﻭﺳﻴﻊ ﺍﺯ ﺗﺤﻘﻴﻘﺎﺕ ﺑﺮ ﺍﺳﺎﺱ ﻓﺎﺭﻣﺎﻛﻮﻟﻮژﻱ ﻣﻌﻜﻮﺱ ﺍﻳﺠﺎﺩ ﻧﻤﻮﺩ ﻭ ﺑﻪ ﻛﻤﻚ ﺁﻥ ﺑﻪ ﺗﻔﺴﻴﺮ ﺑﻬﺘﺮﻱ ﺍﺯ ﻓﻠﺴﻔﻪ ﻱ ﺗﺮﻛﻴﺐ ﺍﺟﺰﺍ ﺩﺭ ﻓﺮﺁﻭﺭﺩﻩ ﻫﺎﻱ ﺳﻨﺘﻲ ﭘﺮﺩﺍﺧﺖ.