مقايسه سيستم ايمني سلولي بيماران مبتلا به فازمانياي اختلال دوقطبي نوع يك با افراد سالم

Comparison of cell mediated immunity in manic phase patients (bipolar I) with normal subjects

Introduction: Relationship between psychiatric disorder and immune system has been the center of interest among researchers for years. Recent findings concerning the impairment of immunity in depressed patients has provided valuable clues for .further research and understanding the multiple aspects of psychiatric disorders. But, there is almost lack of evidence about immunity in bipolar disorders. In this study, our aim was to evaluate the immune system of patients with bipolar I disorder (during manic episode) compaired with normal subjects. Methods: Twenty jour manic patients (15 male, 9female) and 26 normal subjects (15 male, 11 female) aged 15-50 were clinically interviewed by authers and underwent the study. At entry (be/6r treatment with lithium and haloprideol) a book/ sample was taken .from all subjects and the function status of cellular immunity was evaluated by measuring lymphocyte transformation test (LT7 against PHA Mitogen and indices of T cell. function including: CD4, CD8, CD3 and CD4/CD8 ratio as well as CD56; an index of natural killer cells. The measurement were repeated for all subjects 2 months, after clinical remission of patients. Results: T- test and Levene ʹs test showed a significant dffernnce between patients and control subjects in LTT but not in other indices. The proliferation of the patients ʹ lymphocytes was lower in comparison to the subject group, but regarding variables such as CD4, CD8, CD3, CD4/CD8, CD56 there was no significant difference. Conclusion: The results are an evidence for impairment in cellular immune system of bipolar I patients (manic phase) and show that the proliferation of immume cells against mitogen was lower than the control group hut it needs more reseach about this issue.