تحولات فروژنيك هسته هاي رافه در جنين موش بزرگ آزمايشگاهي

Neurogenic shifting of raphe nuclei in ratʹs embryo

Introduction: More than 70% of serotonergic neurons have concentrated in raphe nuclei. Raphe nuclei have rested in a rostrocaudal arrangment. They are a neuronal assembling that have joined to gether in midline and appears raphe.To cosideration of important role of serotonin in vital activity, it is necessary that become clear; how is forming the raphe nuclei. Because of resembling between the ratʹs raphe nuclei and these nuclei in human, the manner of raphe nuclei birth was examined. Materials and Methods: The 5 embryo of albino rat in 14, 16, 18 and 19 days gestation after sending out of uterus were fixed with boins solution and stained with Kluver&Barrera method. The samples were cutted and evaluated with light microscope.Results: Histological findings showed that in 14th day of gestation, two cell groups formed symmetrically; superior (rostral) and inferior (caudal) groups.Conclusion: Rostral cells produce dorsal, median, pontis and magnus raphe nuclei. Caudal cells are the origin of pallidus, obscurus, and magnus raphe nuclei.