كاربرد آپروتينين در كاهش خون ريزي و مصرف پلاسماي تازه بعد از عمل جراحي عروق كرونر

USAGE OF APROTININ FOR REDUCING OF POSTOPERATIVE HAEMORRHAGE AND FRESH FROZEN PLASMA CONSUMPTION

Introduction: Aprotinin has been used increasingly to reduce postoperative blood loss in open - heart operation. Because of itʹs potential for complications and high cost, it will be reasonable to use aprotinin more selectively in small dose in prime solution of pump. Materials & Methods: We prospectively studied the effect of preoperative low dose aprotinin [2 million units (230 mg)] on blood loss and transfusion requirement in patients undergoing cardiopulmonary bypass. 150 patients were randomly assigned to two groups: prophylactic low dose aprotinin (group]) and a non - medicated control group (group2). The two groups were compared in all demographic and operative variables. Results: Postoperative chest tube drainage was significantly decreased in aprotinin group compared with the control group (372, 73 ml in group] and 4822 ml in group2, p<0.05) no significant difference was seen between two group in transfusion requirement (p>0.05). The use of fresh frozen plasma in group] was significantly less than in group2 (469,87 ml versus 680,69 ml p<0.05). Discussion: Our results suggest that prophylactic aprotinin reduces blood loss and FFP requirements compared with non - medicated group. Prophylactic use of aprotinin has been shown to decrease postoperative blood loss and transfusion requirements in patients undergoing cardiac operations with extracorporeal circulation.