اثرات آلومينيوم خوراكي بر غلظت گلوكز ناشتا و پس از تست تحمل گلوكز در موش صحرايي

The Effects of Oral Aluminium Intake on Fasting Plasma Glucose Concentration and after Glucose Tolerance Test in Rat

Background: There is not strong evidences of aluminium (A13+) toxicity by ingesting the food containing A13+, but ingesting these food continuously may lead to A13+ toxicity. However recent studies have strongly emphasized on A13+ toxicity in chronic renal failure patients and also patients who have been administered aluminium containing antacids. In this study the effect of different amounts of A13+ on fasting plasma glucose (FPG) and after glucose tolerance test (GTT) has been investigated in rats. Materials and Methods: Six groups (9 in each group) of male and female Albino rats (180-220g body weight) were fed with food containing A1^3+ [75, 212.5, 312.5, 625, 1250, and 2500 mg/kg (PPm) food] for two months and one control group was fed with normal food. Every 15 days FPG was measured and GTT (45 minutes after administeration of 1g/kg glucose orally) was done in all groups. Results: The results indicated that A1^3+ can increase FPG and impair glucose tolerance in a dose and time dependent manner. FPG of the control group after 60 days intervention (113.8±4 mg/dl) was significantly lower than the case-group, which consumed food containing 2500 mg/kg A1^3+ (165.9±10 mg/dl). The results also indicated that in groups consuming A1^3+ (625, 1250 and 2500 ppm) the weight was reduced significantly at day 60 compare to the control group. Conclusion: The results of this study revealed for the first time, that the toxic effect of aluminium on glucose metabolism must be considered, particularly in individuals with frequent exposure to this element, which could lead to diabetes.