مقايسه رژيم درماني اسيد سالسيليك 2 درصد و بتامتازون با روغن ماهي موضعي در بهبود علايم پسوريازيس

Comparison of acid salisylic 2% and betamethasone with topical fish oil

Background: Psoriasis is a chronic skin disease which is treated with wide range of topical and systemic drugs . Most of researchers have approved the effect of oral fish oil in the treatment of psoriasis but any improvement in psoriasis lesion wasnʹt seen by others . Objective: To evaluate the effect of topical fish oil versus salisylic acid and betamethasone in treating psoriasis . Methods: This randomized double blind clinical trial was carried out on 39 patients with psoriasis vulgaris. They were randomly divided into two groups The first group ( 20 patients) were treated with topical salisylic acid and betamethasone . The second group (19 patients ) were treated with topical fish oil . The patients were evaluated in beginning and 2 months after treatment. Finally the obtained data were analyzed using SPSS package, t-test, chi-square and paired t-test. Findings: Decrease of erythema and skin lesion size in the first group were more than second group at the end of treatment , but there werenʹt significant differences . Decrease of scaling in the first group was more than second group at the end of treatment and this difference was significant (P< 0.05). Conclusion: Topical fish oil is efficient in treatment of psoriasis vulgaris.