سنتز و اثرات ضد تشنج 2- (2- آلكيل تيو-1- بنزيل -5- ايميدازوليل ) -2،3،4- تري هيدرو1-،3،4- تيادي آزول ها در موش كوچك

Synthesis and anticonvulsany effects of 2-(2-alkylthio-l- benzyl -5- imidazolyl) -2,3,4-trihydro- 1,3,4-thiadiazoles in mice

Starting from 1-benzyl-2- mercapto-5-hydroymethylimidazole which is prepared readily, a series of novel 2-( 2-alkylthio -l-benzyl-5-imidazolyl) -2,3,4- trihydro-5- imino- 1,3.4- thiadiazoles [4a-c] were synthesized through multiple steps. The anticonvulsant activities of the title compounds [4a-c] were studied in mice in order to identify more potent anticonvulsant agents. In maximum electroshock test except 4a other compounds [4b,c] decreased the duration of tonic seizures. These results indicate that they may have beneficial effects in grand mal seizures, but their potency, compared with diazepam was very lower .