بررسي تاثير فلوكستين بر كاهش قندخون ناشتا در بيماران ديابتي نوع II

Non Insulin Dependent Diabetic Mellitus (NIDDM) is the most common type of diabetes . Diabetic patients aiming to control their blood sugar have to use anti-diabetic table is . However , after a period , resistance to antidiabetic medicines develops and use of high dosage of medicine cannot reduce the blood sugar . Most of these patients donʹt like to inject insulin and therefore other oral drugs capable of decreasing blood sugar levels are considered important . From several studies , it has been shown that some non- antidiabetic medicines such as fluoxetine cause a reduction in blood sugar . In this study the effect of fluoxetine (inhibitor of returning serotonin ) on reduction of fasting blood sugar was evaluated . A clinical trial study (before and after) was done . Forty two NIDDM patients (10 males and 32 females) with a BMI> 25 and average FBS< 250 were randomly selected . They were given 40mg fluoxetine day for & weeks . Fasting blood sugar was measured after the 4th and 8th weeks following treatment with fluoxetine & then 4 weeks after discontinuation of fluoxetine .The results were analysed by "t-student test" using spss for windows. Average fasting blood sugar in patients at the first time (before taking fluoxetine) was 181mg/d1 . The average FBS of patients after 4 and 8 weeks of fluoxetine use were 156 mg/dl and 149mg/dl respectively. The FBS at 4 weeks after discontinuation of fluoxetine was 152 mg/dl . After the first four weeks of fluoxetine use , FBS reduced by 24mg/dl and after 8 weeks by 31 mg/dl . From our results it could be concluded that fluoxetine can decrease the fasting blood sugar and it Can be prescribed as a complementary drug in diabetics.