بررسي اثر ضدتشنجي عصاره هيدروالكلي سنبل الطيب VALERIANA OFFICINALIS L. در موش كوچك و ارتباط آن با نيتريك اكسايد

The anticonvulsant effect of Valeriana oficinalis roots and rhizomes hydroalcoholic extract was studied, utilizing maximal electroshock (MES) and pentylenetetrazole (PTZ) tests. In the PTZ test, the extract (0.3-3 g/kg, ip) increased the onset time of Tonic Hind Limb Extension dose-dependently. In the MES test, neither of doses showed antiseizure activity. L-NAME (1-10 mg/kg ip) reduced the anticonvulsant effect of extract in the PTZ test. The results suggest that Valeriana oficinalis extract could be a candidate for treatment of petitmal seizure and nitric oxide may be involved in this effect.