بررسي تاثير ملاتونين بر رفتار جنسي موش صحرايي نر مبتلا به ديابت

Effect of Melatonin on Sexual Behavior in Male Diabetic Rats

Introduction: Several clinical studies indicate deterioration of sexual behavior in diabetic patients. The pathophysiological mechanisms of diabetic sexual impotence remain obscure. In this study the therapeutic effects of melatonin on sexual behavior were investigated through the central serotonergic system in diabetic rats. Materials and Methods: In this study, 30 male adult Wistar rats, weighing 200±20 g, were used. Animals were divided into three groups, the controls (C), diabetic (0) and the melatonin-treated diabetic (M) group. Experimental diabetes was induced by intraperitoneal injection of 50 mg/kg streptozotocin. Melatonin was injected (10 mg/kg i, p. ) after 3 days of streptozotocin injection for 30 days. At the end of the administration period, the sexual behavior of each male rat to an ovariectomized female rat was assessed for 40 min. Serotonergic type 2 (5-HT,.) receptor activities were investigated through spontaneous WOS behavior, and experimental data were statistically analyzed. Results: First mount, first intromission and first ejaculation latencies significantly (p