بررسي اثرات هيستوپاتولوژيك گاز دي اكسيد گوگرد در مسموميت حاد و مزمن كبد موش هاي سوري

The histopathologic effects of sulfur dioxide in mouse liver following the chronic and acute exposure

Introduction: Sulfur dioxide (S02) is a dangerous and poisonous gas of pollutant air in industrial countries, It is used 10 produce sulfuric acid and other industrial substances. Since many people are exposed to this gas daily, in this study, we examined the histopathologic effects of gas on the mouse liver in both acute and chronic exposures. Materials and Methods: 28 male mice were divided into 4 groups. Groupl (Gl ) as the control one (not exposed to gas), group2 (G2) which were exposed to high doses of sulfur dioxide (100 ppm) and group3 (03)& group4 (G4)which were exposed to a low dose of sulfur dioxide for 5 minutes for I to 3 weeks(20 ppm). Finally, the mice were slaughtered. First, the livers were assessed macroscopically and then a biopsy on the livers was assessed microscopically. At last the data were analyzed statistically. Findings: The results show that the mean number of Kupffcr cells in G2, G3, and 0 4 significantly increased compared with the control group (9 ±1.0, 10±1.0, II ±l.2 vs 7 ±l.4: p