بررسي نقش سيستم كولينرژيك در اثرات تقويتي گلوكوكورتيكوئيدها بر تثبيت حافظه در موش سوري

Evaluation the role of cholinergic system in glucocorticoids-induced enhancement of memory consolidation in mice

Objecdves: Many evidence indicated that glucocorticoids enhanced memory consolidation in a variety of tasks, but the underlying mechanism(s) are not clear. The aim of this study was to determine the role of cholinergic system in glucocorticoids-induced enhancement of memory consolidation in mice. Methods: In this experimental study were performed on 100 male albino ntice (about 30 g). The animals were trained in an inhibitory avoidance task (0.5 rnA shock for 3 seconds). In Experiment I, effects of corticosterone were deterntined. Immediately after training, the animals received of vehicle or corticosterone (0.3 rng/kg). In Experiments 2 and 3, effects of corticosterone were exantined in the presence of absence of atropine, a blocker of muscarinic cholinergic receptors, (0.5 and 2 mgikg) or Mecamylamine, a blocker of nicotinic cholinergic receptors, (0.5 and 2 rag/kg), respectively. In all experiments, memory retention tested 48 hr later. Results: Results indicated that Corticosterone enhanced memory consolidation significantly (P