بررسي اثر خوراكي گياه والك بر فعاليت انقباضي آئورت ايزوله موش صحرايي ديابتي

Survey the Effect of Feeding of Allium Latifolium on Contractile Reactivity of Aorta of Diabetic Rats

Introduction: Diabetes mellitus is accompanied with a higher incidence of cardiovascular disorders and atherosclerosis. With regard to antidiabetic potential of derivatives of Allium latifolium (AL), the effect of oral administration of this plant on the contractile reactivity of isolated aorta in diabetic rats was investigated during 6 weeks. Objective: Survey the Effect of Feeding of Allium Latifolium on Contractile Reactivity of Aorta of Diabetic rats. Materials and Methods: In this study male wistar rats (0=32) were randomly divided into 4 groups, i.e. control, At-treated control, diabetic, and At-treated diabetic groups. For induction of diabetes. streptozotocin (60 mglkg: i.p.) was used The treatment groups received oral administration of plant-mixed standard pelleted food (6.25%) for 6 weeks. After 6 weeks, contractile reactivity of aortic rings to KCI and nor adrenaline was determined by using isolated tissue setup. Results: Serum glucose level in diabetic group increased during 6 weeks after the experiment as compared with one week before the study (p