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Effect of Testosterone on Thyroid Function in Iodine Deficient Castrated Rats

Introduction: The prevalence of goiter, especially in iodine deficient regions, is higher in women than men. This investigation was conducted to determine the effect of testosterone on thyroid weight and function in iodine deficient normal and castrated rats. Materials and Methods: Male Wistar rats were divided into 6 groups, of 7 animals each: Castrated, hormone treated (C+T), castrated, non-hormone treated (C+NT), normal (N), iodine deficient diet, castrated, hormone treated (ID+C+T), iodine deficient diet, castrated, non-hormone treated (ID+C+NT), iodine deficient diet, normal (IO+N). Three weeks after castration, the C+T and ID+C+T groups received daily intraperitoneal injections of 1 mg/kg testosterone enontate, for 9 weeks. At the end , of the study, we measured thyroid weight and serum testosterone, T4, free T4, T3 and TSH and urinary iodine concentrations. Results: Serum testosterone levels significantly decreased in the C+NT and 10+C+NT groups (p