رفتارهاي شبه اضطرابي ايجاد شده با هيستامين در موش هاي صحرايي حساس شده به مورفين

Anxiety-Related Behaviors Induced by Histamine in Morphine Sensitized Rats

Objective: In the present study, the effect of bilateral intrahippocampal administration of histamine on anxiety-related behavior in rats was investigated. Method: The rats were first sensitized through 3 days of morphine administration and a 5 day drug-free period. The animals were then examined in a plus shaped maze. Results: Intra-VHC bilateral administration of histamine decreased %OAT (Open Arm Times) and %OAE (Open Arm Entries) but not locomotor activity, thus showing an anxiogenic response. However, the administration of histamine to morphine-sensitized rats increased OAT and OAE in comparison with saline administered groups, which is indicative of a decrease in anxiety in the sensitized animals. Conclusion: Bilateral administration of histamine in ventral hippocampus induces an anxiogenic effect, which decreases in morphine sensitized rats. Naloxane antagonizes the effects of morphine on anxiety.