بررسي ميزان iso-prostaglandin 8 آزاد در زنان حامله مبتلا به پره اكلامپسي و مقايسه آن با زنان حامله با فشار خون طبيعي

Plasma free 8-iso-PGF2alevels in normotensive and preeclamptic pregnancies

Background: Preeclampsia is a main cause of morbidity and mortality of pregnant women worldwide. Recently oxidative stress was considered as a part of pathophysiolgy of preeclarnsia and 8-isoprostaglandin F2o. (8-iso-PGF2a) is known as a marker of oxidative stress. The purpose of this study was to measure and compare plasma concentration of free 8-iso-PG F2o. in women with normotensive and preeclamptic pregnancies. Materials and methods: In this descriptive-analytic study, Plasma free 8-iso-PGF2o. levels were measured in pregnant women with preeclamsia (n=42) and normotensive pregnant women (n=39) between 28-38 weeks of gestation . Women in two groups were matched in age, gestational age and socioeconomic statue and all women were nulligravid. Results: Free 8-iso-PGF2a levels were not significantly different in women with preeclamsia and normotensive group (17808 vs. 24288 pg/dl, NS). Plasma free 8-iso-PGF2a levels were increased in severe compared to mild preeclampsia (NS) . Neonates weight of preeclamptic mothers was significantly [ower than neonates of normotensive women (p