مطالعه فراكتالي بر روي حاشيه هسته سلول هاي سرطاني در سيتولوژي ادرار

FRACTAL STUDY ON NUCLEAR BOUNDARY OF CANCER CELLS IN URINARY SMEARS

Background & Aims: Cancer is a serious problem for human being. A necessary prerequisite for any therapeutic modality is early diagnosis. Fractal dimension measurement of nuclear boundary of cancer cells can be used as a feature extraction in the field of automated cancer diagnosis. Materials & Methods: 41 positive urine cytology and 33 negative ones were selected randomly. Digitalized images prepared using objective 100X and a digital video head preprocessed subsequently and the fractal dimension ofnuclear boundaries was measured by a software. Re.•ults: Findings revealed a statistically significant difference between fractal dimensions of nuclear boundaries of cancerous versus non-cancerous in urinary smears. Selecting a proper cut off point (1.732 ± 0.006 in this study) can discriminate malignant and non-malignant epithelial cells in urinary smears. Conclusion: Based on diagnostic accuracy measures (sensitivity and specificity), probability of disease measures (predictive value of a positive and negative test results), and likelihood ratio of positive and negative tests, it seems fractal dimension of nuclear cell boundaries in urinary smears can be used as a feature extraction in the field ofautomated cancer diagnosis.