آيا كاربرد N2O حين القاي بيهوشي اطفال موجب بروز اثر معكوس ناشي از تحريك دردناك در مانيتورينگ BIS مي شود؟

Dose NzO Cause Paradoxical Reaction in Response to Noxious Stimulants During Inhalation Induction of Anesthesia in Pediatrics?

Bispectral Index is one of the qualitative methods of measuring of sedation and depth of anesthesia. In a few studies appeared a paradoxical effect of N20 on BIS in adults. In this study, the paradoxical effects ofN20 during inhalation induction of anesthesia in pediatrics by halothane and isoflorane were evaluated. In a clinical trial study, eighty 1-6 year old age, ASA I and II pediatrics who candidate for abdominal and extremities elective surgeries were evaluated in 4 groups (Halothane, Isoflorane, Halothane plus N20 and Isoflorane plus N20). Anesthesia was induced by gradual increase of vapor gas in 100% of O2 in groups I and 2 and in 50% ofN20 in O2 in groups 3 and 4. BIS and other variables were measured before and after of laryngoscopyand surgical incision. The mean of percent changes of BIS after the laryngoscopy in comparison to pre-laryngoscopy in 4 groups were: 0.15 ± 13.95, 16.57 ± 19.49, 4.90 ± 42.68, and 31.22 ± 28.19 (P = 0.287). The pre and after surgical incision BIS were: -3.88±23.30, 19.36 ± 9.17, 16.73 ± 2.33, and 7.75 ± 13.3 (P = 0.121). This study could not confirm appearance of paradoxical effects ofN20 on BTS during inhalation induction of anesthesia in pediatrics