بررسي سطح پلاسمايي آنتي بادي هاي (IgG1، IgG2) در افراد مبتلا به پريودنتيت و گروه كنترل

Plasma antibody levels (IgGl .IgGʹ2) in periodontitis and control groups

moment" of Epidemiology and Biostatistics. School of Public Health, Tehran University of Medical Sciences : --partmemeni of Prosthodontics, Scho< ! of Dentistrv Tehran University of Medical Sciences Bsc Aground ad Aim: A major aspoci of the adaptive host response in periodontitis is the antibodies. Several risk-: and susceptibility factors for pairMnutis. including smoking, age and composition of the subgingival microflora, have also been suggested to influence antibody production. The present study was conducted to investigate plasma levels of immunoglobulin fig) G antibodies in periodontitis patients of Caucasian Iranian heritage referred to dental facultv. Tehran Universitv of Medical Sciences in relation to disease severity and smoking. Materials and Methods: In this study, 36 patients with severe periodontitis, 39 with moderate periodontitis and 40 controls without periodontal destruction were enrolled. From the total of SO patients, 21 were diagnosed with aggressive periodontitis and 54 with chronic periodontitis. IgG isotvpes were analyzed in plasma samples. Results: Patients group m comparison with control group had shown higher level of Immuno globolins. There was no significant difference about the IgGl level m moderate and severe group and also in chronic and aggressive groups (p<0/00l). But the level of IgG2 was shown the significant difference m the all study groups. Smoking was significantly reduced the level of IgGl and IgG2. Conclusion: The current study shows that non-smoker periodontitis patients have higher levels of IgG2 than smoker periodontitis patients.