تاثير عصاره هيدروالكلي گياه بيلهر (Dorema aucheri) بر هورمون هاي تيروييدي در موش صحرايي نر بالغ

The effect of Dorema aucheri-Hydroalcoholic extracts on thyroids hormones in adult male rats.

Background and aim: Flavonoids constitute a large group of polyphenolic compounds that have antioxidant properties. Dorema aucheri plant has antioxidant materials and in this study we evaluated the effects of Dorema aucheri-hydroalcoholic extract on thyroids hormones in adult rats. Methods: In this experimental study, 50 wistar adult rats were divided into 5 groups of 10 animals as follow: first group was control; the second group, i.e. sham group, received distilled water and the other 3 groups received different doses of hydroalcoholic extracts of Dorema aucheri (100, 200 and 400 mg/kg, respectively). Thyroid hormones (TSH, T3 and T4) were determined after 3 weeks of extract consumption. Data were analyzed by useing of Kruscal Walis and Donn test,. Results: Following 3 weeks administration of Dorema Aucheri extracts on rats, we found a significant increase in TSH hormone levels in the lowest dose (P<0.05). No significant change was seen in other doses (P>0.05). In addition, the concentrations of T3 and T4 hormones were not changed (P<0.05).