بررسي هيستوپاتولوژيك تأثير داروي سلكوكسيب در كنترل التهاب حاد ناحيه پري آپيكال پس از درمان ريشه در گربه

Histopathologic Study of the Effect of Celecoxib to Control Acute Periapical Inflammation after Root Canal Treatment in Cats

Introduction: Prostaglandins are important inflammatory mediators that their synthesis is mediated by cyclooxygenase enzyme. Therefore, non steroidal anti inflammatory drugs (NSAIDs) that can prohibit this enzyme, are widely used for pain control after root canal treatment. The purpose of this study was to evaluate the effectiveness of Celecoxib in control of acute apical inflammation following root canal treatment in cats.Methods and Materials: In this experimental animal study, 24 canines and 4 premolar (as negative control) teeth of 6 cats were studied. The cats were divided into two experimental groups: the first group received 2.5mg/kg Celecoxib orally one hour before treatment and the second group did not receive any drug. After root canal treatment, animals were sacrificed by vital perfusion technique at different intervals (8, 12 or 24 hours). The samples then evaluated histologically according to three inflammatory factors: intensity of inflammatory cells, edema and vasodilatation. The results were analyzed statistically using the Kruskal-wallis and Mann-Whitney tests.Results: There were significant differences between two groups in the three inflammatory criteria at 8 hours after the treatment (p value<0.05). There were significant differences between two groups in the intensity of inflammatory cells and edema at 12 hours after the treatment (p value<0.05). There was significant difference between two groups in the edema at 24 hours after the treatment (p value<0.05). Conclusion: This study showed that Celecoxib could reduce the acute inflammation of periapical tissue after root canal therapy.