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Immunopathogenesis of Brucellosis

stimulation activity of Bactericidal function in Macrophages. Th 1 T.Cell production of IFN-gamma activates Macrophages to kill interacellular Bacteria. Th 2 cells produce IL-4 , IL-5, IL-13, IL-9, IL10 and IL-2 5. Editorial Immunopathogenesis of Brucellosis Brucella Organisms have evolved Mechanisms to escape Neutrophil and antibody- mediated Immune defenses. Phagocytic cells entering is the most effective escape mechanism and in this condition The host cell becomes a protective defencse against exatera cellular anti- Microbial defenses. In diagnosis of Brucella infection serologic test is not a gold standard diagnostic assay, Regarding false positive and false negative serologic tests. Blood and Bone marrow culture and tissue PCR are strong tests and have high specificity and sencibility values.