افزايش احتمال متاستاز سرطان كلوركتال در حاملين آلل 5A پروموتور ژن MMP3

Increased Risk of Colorectal Cancer Metastasis in Host of 5A Allele at MMP3 Gene Promoter

Colorectal cancer is the most prevalence malignancy that affect on stomachic system. After lung and breast cancer, colorectal cancer is the most common of death in the western world. Colorectal adenocarcinoma accounts for over 90% of the malignant tumors of the large bowel. Modification in cell adherent molecules and enzymes that degrade intra cellular membrane have important role for colorectal tumor creation. Matrix metalloproteinase enzymes degrade different component of extra cellular matrix and cause tumor creation, cancer development and metastasis. MMP3 overexpression due to single nucleotide polymorphism (SNP) 5A/6A at the -1171 position of the MMP3 gene promoter affects on tumor malignancy and cancer development. A case- control study was performed including 120 cancer patients from Emam Khomeini hospital in Tehran and Seid Alshohada hospital in Isfahan. After MMP3 promoter genotyping, the results were analysed by SPSS 12.0 software. The colorectal cancer patients were divided in to two groups: M+ non- metastasis patients and M-, the metastasis- free patients. The MMP3 genotypes were similar between controls and patients (P= 0.43, OR= 0.78, 95%CI, 0.37-1.64), but the 5A/5A genotype was more prevalent in the M+ groups than controls (P= 0.74, OR= 2.91, 95%CI, 0.94-8.98). This frequency was more prevalent than M-(P= 0.65, OR= 1.90, 95%CI, 0.69-5.2). So we supposed the MMP3 5A/6A promoter polymorphism doesnʹt appear to influence colorectal among colorectal cancer patients but 5A/5A genotype with MMP3 over-expression cause colorectal cancer development and metastasis.