پديد آورندگان :
Zarei، Ali نويسنده Department of Physiology, Science and Research Branch, Azad University of Damghan, Damghan, Iran Zarei, Ali , Changizi-Ashtiyani، Saeed نويسنده Department of Physiology, Arak University of Medical Sciences, Arak, Iran Changizi-Ashtiyani, Saeed , Sokhandani، Mansour نويسنده Department of Nursing, Shiraz University of Medical Sciences, Shiraz, Iran Sokhandani, Mansour , Rezaei، Azam نويسنده Islamic Azad University of Arsanjan, Arsanjan, I. R. Iran , , Zaheiri، Saeed نويسنده Department of Biology, Payame Noor University of Abadeh, Abadeh, I. R. Iran , , Taheri، Soheila نويسنده Department of Physiology, Arak University of Medical Sciences, Arak, I. R. Iran ,
كليدواژه :
Hypercholesterolemia , Mellissia officinalis , Atorvastatin , Thyroid
چكيده لاتين :
Background: Consumption of unsaturated fats reduces the serum level of lipids and leptin. Thyroid hormones and leptin play pivotal roles in metabolism and their amounts are inter-related. This study was done to compare the effects of Mellissia officinalis extract and atorvastatin on the serum levels of thyroid hormones in hypercholesterolemia rats.
Materials and Methods: Consumption of unsaturated fats reduces the serum level of lipids and leptin. Thyroid hormones and leptin play pivotal roles in metabolism and their amounts are inter-related. This study was done to compare the effects of Mellissia officinalis extract and atorvastatin on the serum levels of thyroid hormones in hypercholesterolemia rats.
Results: The results showed that in experimental groups receiving the plant extract and atorvastatin, the concentration of thyroid hormones increased, whereas the amount of the thyroid-stimulating hormone showed a significant decrease (p < 0.05).
Conclusion: Mellissia officinalis extract decreases TSH but it increases T3 and T4. Further studies are required for applying this extract to the treatment of hyperthyroidism.
