شماره ركورد
626161
عنوان مقاله
Association of DD Genotype of Insertion/Deletion Polymorphism of Angiotensin-Converting Enzyme Gene with Systemic Lupus Erythematosus and Lupus Nephropathy
پديد آورندگان
Salimi، Saeedeh نويسنده Department of Clinical Biochemistry, Cellular and Molecular Research Center, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Salimi, Saeedeh , Naghavi، Anoosh نويسنده Department of Clinical Biochemistry, Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Naghavi, Anoosh , Zakeri، Zahra نويسنده Department of Internal Medicine, Clinical Research Development Center, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Zakeri, Zahra , Nabizadeh، Sima نويسنده Department of English, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Nabizadeh, Sima , Farajian-Mashhadi، Farzaneh نويسنده Department of Pharmacology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Farajian-Mashhadi, Farzaneh , Sandoughi، Mahnaz نويسنده Department of Internal Medicine, Clinical Research Development Center, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Sandoughi, Mahnaz
رتبه نشريه
-
تعداد صفحه
5
از صفحه
69
تا صفحه
73
كليدواژه
Polymorphism , systemic lupus erythematosus , Lupus nephropathy , IRAN , angiotensin-converting enzyme
چكيده لاتين
Background: Systemic lupus erythematosus (SLE) is a multisystem disease with unknown etiology. We hypothesized that insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) gene may influence the development and/or progression of SLE and lupus nephritis.
Materials and Methods: In a crass sectional case-control study, genomic DNA from 106 SLE patients and 103 healthy controls matched for sex, age, and ethnicity, were genotyped for the (I/D) polymorphism of ACE gene by polymerase chain reaction (PCR). Comparison of quantitative variants between two groups was assessed by student t-test and association between qualitative variables was analyzed by the chi-square or Fisher exact tests.
Results: The frequency of DD genotype in SLE patients was significantly higher than control group (25.5 % vs. 14 %), and the risk of SLE was 2.2 times greater in subjects with DD genotype than the individual by DI and II genotypes (OR, 2.2 [95% CI, 1.1 to 4.4]; p=0.023). The distribution of D allele in SLE patients was significantly higher (p=0.021) compare to controls (47 and 36.4, respectively). The Risk of nephropathy in SLE patients with DD genotype was three times more than other genotypes (OR), 3 [95% CI, 1.1 to 8]; p=0.027].
Conclusion: This study demonstrated that ACE DD genotype acts as a risk factor on SLE and Lupus nephropathy in an Iranian population.
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