پيامد بارداري در افراد مبتلا به سو مصرف مواد

THE EFFECT ON PREGNANCY OUTCOME OF DRUG (SUBSTANCE) ABUSE DURING PREGNANCY

پيش زمينه و هدف: سو مصرف مواد در طي حاملگي يكي از مسايل مهم از نظر سلامت مادران و نوزادان مي‌باشد. شناسايي عواقب بد حاملگي در اين افراد مي‌تواند در جهت كنترل آن‌ها كمك دهنده باشد. هدف از مطالعه حاضر تاثير سو مصرف مواد در طي حاملگي بر روي پيامدهاي حاملگي است. مواد و روش كار: مطالعه به صورت كوهورت تاريخي Historical Cohort بين دو گروه از زنان مبتلا به سو مصرف مواد و زنان حامله بدون سو مصرف مواد صورت گرفت. در هر دو گروه زنان ايراني، خانه‌دار، حاملگي تك قلو و بدون سابقه هيچ‌گونه بيماري سيستميك در نظر گرفته شدند. يافته‌ها: در مجموع 1268 زن حامله مورد بررسي قرار گرفتند كه 317 نفر از آنان مبتلا به سو مصرف مواد و 951 نفر بدون سو مصرف مواد بودند. بيماران دو گروه از نظر جنس جنين، مدت حاملگي، فشار خون ناشي از حاملگي، مرگ داخل رحمي IUFD، و پارگي كيسه آب با يكديگر تفاوت معني‌دار نداشتند (P=0.000) . سن مادر (P=0.000)، وزن مادر (P=0.000)، وزن تولد (P=0.000) در مادران معتاد كم‌تر بود. زايمان سزارين RR=1.1 (1.02-1.12) (P=0.049) ? سابقه سقط (P=0.000)، گراويديتي (P=0.000)، پلاسنتال ابراپشن ( دكلمان يا كنده شدن زودرس جفت ) RR=2.7 (1.8-4.1)(P=0.023)، دفع مكونيوم RR=2.6 (2.3-2.8)(P=0.000) ? وزن تولد كم‌تر از 2500 گرم RR=1.9 (1.8-2) P=0.000) )، آپگار كم‌تر از 7 در دقيقه 5 RR= 1.7 (1.5-1.7)) P=0.001) )، پذيرش در NICU RR=3.7 (3.5-3.8)(P=0.000) و مرگ نوزادان RR=2.1 (1.8-2.5) (P=0.009) در گروه معتاد بيشتر بود. نتيجه گيري: سو مصرف مواد سبب عواقب بد حاملگي مي‌شود و كنترل از نظر سو مصرف مواد اين عاقبت را بهبود مي‌بخشد.

Background & Aims : Substance abuse during pregnancy is one of the most important problems in maternal and neonatal health. Being familiar with the risk of poor pregnancy outcome in these individuals may help them to reduce that risk. The purpose of the present study is to evaluate the effects on Pregnancy outcome of substance abuse during pregnancy. Materials & Methods : The study was conducted as a historical cohort study between two groups of pregnant women with or without substance abuse. Both groups were Iranian housewives, with the same socio economical status, singleton and without any known medical systemic disorder. Results : 1268 women were evaluated in total. 317 women were drug abusers and 951 women were not. The woman in both groups had no significant differences according to neonates’ gender, gestational age, pregnancy-induced hypertension, intra uterine fetal death (IUFD), and ruptured membranes. Maternal age (P=0.000), maternal weight (P=0.000), neonatal weight (P=0.000) were found to be lower in drug abusers. History of previous abortion (p=0.000) and gravidity (P=0.000) were higher in drug abusers. Also cesarean delivery [(P=0.049, RR=1.1 (1.02-1.12)], placental abruption [(P=0.000, RR=2.7 (1.8-4.1)], meconium passage [P=0.000, RR=2.6 (2.3-2.8)], neonatal weight of less than 2500 gram [P=0.000, RR=1.9 (1.8-2)], Apgar score of less than 7 in minute 5 [P=0. 001, RR= 1.7 (1.5-1.7)], NICU admission [P=0.000, RR= 3.7 (3.5-3.8)] and neonatal death [P=0.009, RR= 2.1 (1.8-2.5)] were all higher in drug abusers. Conclusion : Substance abuse causes poor outcomes in pregnancy, and with control, patients may improve these poor conditions. Keywords : Substance abuse, drug abuse, pregnancy, pregnancy outcomes, low birth weight, Apgar Score, NICU, pregnancy induced hypertension (PIH), placental abruption. Keywords: Substance abuse, Drug abuse, Pregnancy, Pregnancy outcomes, Low birth weight, Apgar Score, NICU, Pregnancy induced hypertension (PIH), Placental abruption, Full text [PDF 148 kb] * Corresponding Author Address: No 9, Mostaghimi Alley, Khajeh Nasir Toosi Avenue, Postcode 16117, Tehran, Iran, Tel: +98-21-77523487 How to cite this article Download citation data for: BibTeX | EndNote | Medlars | ProCite | Reference Manager | RefWorks | Send citation data to: CiteULike | RefWorks | Kashanian M, Baradaran H, Hatami H, Ghasemi A. THE EFFECT ON PREGNANCY OUTCOME OF DRUG (SUBSTANCE) ABUSE DURING PREGNANCY. URMIA MEDICAL JOURNAL. 2013; 23 (7) :752-760 URL http://umj.umsu.ac.ir/browse.php?a_code=A-10-582-313&slc_lang=en&sid=1 Send email to the article author Add your comments about this article Your username or email: Write the security code in the box >