Title of article :
Accurate template-based correction of brain MRI intensity distortion with application to dementia and aging
Author/Authors :
M.، Weiner, نويسنده , , C.، Studholme, نويسنده , , V.، Cardenas, نويسنده , , E.، Song, نويسنده , , F.، Ezekiel, نويسنده , , A.، Maudsley, نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Pages :
-98
From page :
99
To page :
0
Abstract :
This paper examines an alternative approach to separating magnetic resonance imaging (MRI) intensity inhomogeneity from underlying tissue-intensity structure using a direct template-based paradigm. This permits the explicit spatial modeling of subtle intensity variations present in normal anatomy which may confound common retrospective correction techniques using criteria derived from a global intensity model. A fine-scale entropy driven spatial normalisation procedure is employed to map intensity distorted MR images to a tissue reference template. This allows a direct estimation of the relative bias field between template and subject MR images, from the ratio of their low-pass filtered intensity values. A tissue template for an aging individual is constructed and used to correct distortion in a set of data acquired as part of a study on dementia. A careful validation based on manual segmentation and correction of nine datasets with a range of anatomies and distortion levels is carried out. This reveals a consistent improvement in the removal of global intensity variation in terms of the agreement with a global manual bias estimate, and in the reduction in the coefficient of intensity variation in manually delineated regions of white matter.
Keywords :
immunoglobulin G , Quantum dots , Fluorescence resonance energy transfer
Journal title :
IEEE Transactions on Medical Imaging
Serial Year :
2004
Journal title :
IEEE Transactions on Medical Imaging
Record number :
100778
Link To Document :
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