In situ electrochemical contact angle study of the biorecognition based on C60DF monolayer interface

In this study, the specific DNA binding behavior of a water soluble C60 derivative (C60DF) and redox-controlled hydrophilic-to-hydrophobic transformations of the relative C60DF monolayer on surfaces of glassy carbon electrode (GCE) have been demonstrated by using in situ electrochemical static contact angle analysis. The results illustrate that in situ electrochemical contact angle detection based on C60DF functional film can be utilized to sensitively probe some specific bio-molecular recognition like DNA interaction, which will provide the new strategy to develop the promising multi-signal responsive biosensors for relevant biological process.