Title of article
Hypothyroidism in B-Thalassemia Intermedia Patients with and without Hydroxyurea
Author/Authors
Zekavat، Omid Reza نويسنده Hematology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran; , , Makarem، Ali Reza نويسنده Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran; , , Haghpanah، Sezaneh نويسنده , , Karamizadeh، Zohreh نويسنده Department of Pediatric Endocrinology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran , , Javad، Parvin نويسنده Hematology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran; , , KARIMI، MEHRAN نويسنده ,
Issue Information
فصلنامه با شماره پیاپی 0 سال 2014
Pages
4
From page
60
To page
63
Abstract
Hydroxyurea (HU) has been successfully used in patients with B-thalassemia intermedia (B-TI). We aimed to evaluate the effect of the long-term use of HU on thyroid function in patients with B-TI. Seventy-five patients with B-TI aged?11 years and taking HU were randomly selected during 2010 in southern Iran. Thirty-one patients with B-TI without HU were considered as a control group. Serum levels of thyroid stimulating hormone (TSH) and T4 were measured. The mean age of the participants was 22.7±5.1 years (age range=12-41 years). Serum ferritin level had no significant correlation with HU consumption (P > 0.05). Overall, we detected 10 (9.4%) patients with hypothyroidism. We found that the use of HU at a dose of 8-15 mg/kg/day has no significant association with thyroid function in B-TI patients. However, due to the small sample size in our study, documentation of this finding needs further studies with higher numbers of patients.
Journal title
Iranian Journal of Medical Sciences (IJMS)
Serial Year
2014
Journal title
Iranian Journal of Medical Sciences (IJMS)
Record number
1014645
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