Ecstasy, Memory and Sex Differentiation

While Ecstasy (MDMA)use has been associated with a decline in various aspects of mnemonic function in animals and humans, little is known about ecstasy-induced gender differences on learning and memory. The objectives of the present study were to investigate the effect of ecstasy treatment on spatial memory in male and female rats. 28 male and female rats were randomly divided in to 4 male and female control and treatment groups. Treatment groups received ecstasy 10 mg/kg, ip, for 5 consecutive days. characteristic learning and spatial memory was assessed using Morris Water Maze for 5 consecutive days following the treatment period. No significant differences were seen in male Latency, Speed and Pathlengwas compare to females. soits logical to conclude that action of MDMA in CNS areas involved in spatial memory may be independent of sex hormone.