Author/Authors :
Juhong Liu، نويسنده , , Sasha Akoulitchev، نويسنده , , Achim Weber، نويسنده , , Yu Hui Ge، نويسنده , , Sergei Chuikov، نويسنده , , Daniel Libutti، نويسنده , , Xin W Wang، نويسنده , , Joan Weliky Conaway، نويسنده , , Curtis C. Harris، نويسنده , , Ronald C Conaway، نويسنده , , Danny Reinberg، نويسنده , , David Levens، نويسنده ,
Abstract :
Inherited mutations of the TFIIH helicase subunits xeroderma pigmentosum (XP) B or XPD yield overlapping DNA repair and transcription syndromes. The high risk of cancer in these patients is not fully explained by the repair defect. The transcription defect is subtle and has proven more difficult to evaluate. Here, XPB and XPD mutations are shown to block transcription activation by the FUSE Binding Protein (FBP), a regulator of c-myc expression, and repression by the FBP Interacting Repressor (FIR). Through TFIIH, FBP facilitates transcription until promoter escape, whereas after initiation, FIR uses TFIIH to delay promoter escape. Mutations in TFIIH that impair regulation by FBP and FIR affect proper regulation of c-myc expression and have implications in the development of malignancy.
